Three-dimensional Visualization of mRNA Release from Actively-Transcribing Rotavirus Particles

Jeffrey A. Lawton**, Mary K. Estes, and B. V. Venkataram Prasad**

The three-dimensional structure of actively-transcribing rotavirus particles reveals that the nascent mRNA transcripts generated within the core of the virion by endogenous transcriptase complexes are translocated through the intact capsid via a system of channels at the icosahedral 5-fold axes.

* Verna and Marrs Mclean Department of Biochemistry and W. M. Keck Center for Computational Biology
** Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030