Using three-dimensional structural analysis carried out
by a combination of electron
cryo-microscopy, computer
image processing, and X-ray
crystallography techniques, we are able to provide a detailed description
of the structural components of the viruses in the
Reoviridae and Caliciviridae (picture). Recent developments in molecular biology have enabled the expression
of several viral proteins in adequate quantities, allowing us to probe
more into the structural intricacies of these viruses and understand better
the molecular mechanisms that underly various biologic functions related
to viral pathogenesis such as cell entry, neutralization, uncoating, transcription,
replication and assembly.
You are welcome to browse through the abstracts of the recently
published papers written by the members of this research team!
Also visit our new 3D Reconstruction Virus Gallery, here.
Dr. Prasad's Lab can be found in:
Room 376A,
Verna and Marrs
McLean Department of Biochemistry
W.M. Keck Center for Computational
Biology,
Baylor College of Medicine,
Houston, Texas 77030