Software Package Details

Software Name: EM-Fold

Software Licensing: Proprietary (or unreleased)

Software URL: http://bclcommons.vueinnovations.com/licensing

Software Reference: Lindert, S., Staritzbichler, R., Woetzel, N., Karakas, M., Stewart, P.L., and Meiler, J. (2009). Structure 17, 990-1003.

Software Capabilities:

  • de novo protein folding into medium resolution density maps

Software Description:

Both cryo-electron microscopy (cryoEM) and X-ray crystallography frequently yield medium resolution (6 – 10 Å) density maps of large macromolecular assemblies. Generally no atomic detail is resolved in these density maps, making it impossible to deduce the protein structure from the density map alone. We developed a novel computational protein folding algorithm, BCL::EM-Fold, that folds the amino acid chain de novo into density rods observed for α-helices and β-strands at sub-nanometer resolution.

Software Package Details

Software Name: EM-Fold

Software Licensing: Proprietary (or unreleased)

Software URL: http://bclcommons.vueinnovations.com/licensing

Software Reference: Lindert, S., Staritzbichler, R., Woetzel, N., Karakas, M., Stewart, P.L., and Meiler, J. (2009). Structure 17, 990-1003.

Software Capabilities:

  • de novo protein folding into medium resolution density maps

Software Description:

Both cryo-electron microscopy (cryoEM) and X-ray crystallography frequently yield medium resolution (6 – 10 Å) density maps of large macromolecular assemblies. Generally no atomic detail is resolved in these density maps, making it impossible to deduce the protein structure from the density map alone. We developed a novel computational protein folding algorithm, BCL::EM-Fold, that folds the amino acid chain de novo into density rods observed for α-helices and β-strands at sub-nanometer resolution.

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