Software Package Details
Software Name: EM-Fold
Software Licensing: Proprietary (or unreleased)
Software URL: http://bclcommons.vueinnovations.com/licensing
Software Reference: Lindert, S., Staritzbichler, R., Woetzel, N., Karakas, M., Stewart, P.L., and Meiler, J. (2009). Structure 17, 990-1003.
- de novo protein folding into medium resolution density maps
Both cryo-electron microscopy (cryoEM) and X-ray crystallography frequently yield medium resolution (6 – 10 Å) density maps of large macromolecular assemblies. Generally no atomic detail is resolved in these density maps, making it impossible to deduce the protein structure from the density map alone. We developed a novel computational protein folding algorithm, BCL::EM-Fold, that folds the amino acid chain de novo into density rods observed for α-helices and β-strands at sub-nanometer resolution.